No endogenous Aβ production in presenilin-deficient fibroblasts
نویسندگان
چکیده
منابع مشابه
Bidirectional regulation of Aβ levels by Presenilin 1.
Alzheimer's disease (AD) is characterized by accumulation of the β-amyloid peptide (Aβ), which is generated through sequential proteolysis of the amyloid precursor protein (APP), first by the action of β-secretase, generating the β-C-terminal fragment (βCTF), and then by the Presenilin 1 (PS1) enzyme in the γ-secretase complex, generating Aβ. γ-Secretase is an intramembranous protein complex co...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2002
ISSN: 1465-7392,1476-4679
DOI: 10.1038/ncb0702-e164a